AT5G56290.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:cytosol 0.500 peroxisome 0.500 ASURE: cytosol,peroxisome What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : peroxin 5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes the peroxisomal targeting signal type 1 receptor that facilitates peroxisomal protein translocation. It recognizes proteins with the PTS1 consensus sequence (tripeptide SKL or a conserved variant) at the extreme C terminus. The protein has several domains, including C-terminal tetratricopeptide repeat motifs which act in binding the C-terminal "SKL" targeting signal. The mechanism of transport has been worked out in other organisms: The receptor recognizes and binds cytosolic PTS1-containing proteins. The PEX5-PTS1 complex binds a PEX14/PEX13 receptor complex at the peroxisome membrane and is translocated into the peroxisome matrix in a process dependent on PEX2,PEX10, and PEX12. In the peroxisome matrix, PEX5 releases its cargo and is recycled to the cytosol in a process dependent on PEX1, PEX4, PEX6 and PEX22. It is also involved, in conjunction with PEX7, in PTS1- and PTS2-dependent peroxisomal protein import. RNAi experiments suggest that PEX5 is necessary for the maintenance of both glyoxysomal and leaf peroxisomal functions. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
peroxin 5 (PEX5); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G11540.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr5:+:22786655..22791972 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 80916.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 4.46 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.58 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 728 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MAMRDLVNGG AACAVPGSSS SSNPLGALTN ALLGSSSKTQ ERLKEIPNAN RSGPRPQFYS EDQQIRSLPG SELDQPLLQP GAQGSEFFRG FRSVDQNGLG 101: AAWDEVQQGG PMPPMGPMFE PVQPTFEGPP QRVLSNFLHS FVESSRGGIP FRPAPVPVLG LSQSDKQCIR DRSSIMARHF FADRGEEFIN SQVNALLSSL 201: DIDDGIQARG HVPGRFRELD DYWNESQAVV KPNLHPADNW AAEFNQHGMD HGGPDSWVQS FEQQHGVNGW ATEFEQGQSQ LMSSQMRSMD MQNIAAMEQT 301: RKLAHTLSQD GNPKFQNSRF LQFVSKMSRG ELIIDENQVK QASAPGEWAT EYEQQYLGPP SWADQFANEK LSHGPEQWAD EFASGRGQQE TAEDQWVNEF 401: SKLNVDDWID EFAEGPVGDS SADAWANAYD EFLNEKNAGK QTSGVYVFSD MNPYVGHPEP MKEGQELFRK GLLSEAALAL EAEVMKNPEN AEGWRLLGVT 501: HAENDDDQQA IAAMMRAQEA DPTNLEVLLA LGVSHTNELE QATALKYLYG WLRNHPKYGA IAPPELADSL YHADIARLFN EASQLNPEDA DVHIVLGVLY 601: NLSREFDRAI TSFQTALQLK PNDYSLWNKL GATQANSVQS ADAISAYQQA LDLKPNYVRA WANMGISYAN QGMYKESIPY YVRALAMNPK ADNAWQYLRL 701: SLSCASRQDM IEACESRNLD LLQKEFPL |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)