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AT5G22220.2
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : E2F transcription factor 1
Curator
Summary (TAIR10)
Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. Binds DPA and RBR1 proteins. Expressed throughout the cell cycle. Abundance increased by auxin through stabilization of the protein. Elevates CDK levels and activity, even under hormone-free conditions. Promotes cell division and shortens cell doubling time, inhibits cell growth. Transgenic plants overexpressing AtE2Fa contained an increased level of AtE2Fb transcripts that is paralleled by an increase in the amount of the AtE2Fb protein, suggesting that AtE2Fb expression might actually be up-regulated by the AtE2Fa transcription factor.
Computational
Description (TAIR10)
E2F transcription factor 1 (E2F1); CONTAINS InterPro DOMAIN/s: Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 3 (TAIR:AT2G36010.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
Protein Annotations
BioGrid:17558eggNOG:ENOG410XNYIeggNOG:KOG2577EMBL:AB007651
EMBL:AF242580EMBL:AJ294533EMBL:AL589883EMBL:AY136479
EMBL:BT006610EMBL:CP002688EnsemblPlants:AT5G22220EnsemblPlants:AT5G22220.2
entrez:832283Gene3D:1.10.10.10GeneID:832283Genevisible:Q9FV71
GO:GO:0003677GO:GO:0003700GO:GO:0005634GO:GO:0005667
GO:GO:0005737GO:GO:0006351GO:GO:0007049GO:GO:0008284
GO:GO:0009733GO:GO:0010090GO:GO:0045893GO:GO:0051302
GO:GO:0051446hmmpanther:PTHR12081hmmpanther:PTHR12081:SF47HOGENOM:HOG000232044
IntAct:Q9FV71InterPro:IPR003316InterPro:IPR011991InterPro:IPR015633
InterPro:IPR032198iPTMnet:Q9FV71KEGG:ath:AT5G22220KO:K06620
MINT:MINT-8050696ncoils:CoilOMA:TERNMETPANTHER:PTHR12081
PaxDb:Q9FV71Pfam:PF02319Pfam:PF16421Pfam:Q9FV71
PhylomeDB:Q9FV71PRIDE:Q9FV71PRO:PR:Q9FV71ProteinModelPortal:Q9FV71
Proteomes:UP000006548Reactome:R-ATH-113510Reactome:R-ATH-1538133Reactome:R-ATH-68689
Reactome:R-ATH-68911Reactome:R-ATH-69205Reactome:R-ATH-69298RefSeq:NP_001031921.3
RefSeq:NP_568413.1SMART:SM01372SMR:Q9FV71STRING:3702.AT5G22220.2
SUPFAM:SSF144074SUPFAM:SSF46785TAIR:AT5G22220tair10-symbols:ATE2FB
tair10-symbols:E2F1tair10-symbols:E2FBUniGene:At.10189UniProt:Q9FV71
Coordinates (TAIR10) chr5:+:7360749..7364120
Molecular Weight (calculated) 51656.10 Da
IEP (calculated) 4.38
GRAVY (calculated) -0.67
Length 469 amino acids
Sequence (TAIR10)
(BLAST)
001: MSEEVPQQFP SSKRQLHPSL SSMKPPLVAP GEYHRFDAAE TRGGGAVADQ VVSDAIVIKS TLKRKTDLVN QIVEVNELNT GVLQTPVSGK GGKAKKTSRS
101: AKSNKSGTLA SGSNAGSPGN NFAQAGTCRY DSSLGLLTKK FINLIKQAED GILDLNKAAD TLEVQKRRIY DITNVLEGIG LIEKTLKNRI QWKGLDVSKP
201: GETIESIANL QDEVQNLAAE EARLDDQIRE SQERLTSLSE DENNKRLLFV TENDIKNLPC FQNKTLIAVK APHGTTLEVP DPDEAGGYQR RYRIILRSTM
301: GPIDVYLVSQ FEESFEDIPQ ADEPSNVPDE PSNVPDVPSN LPSTSGLPEN HDVSMPMKEE STERNMETQE VDDTQRVYSD IESHDFVDGI MKIVPPDLDM
401: GVDYWFRSEV GEVSITDMWP DESGPDWNQM ITFDQDHAGP SDNKILEQPQ TPSSPTPEES TATRSPTGS
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)