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AT5G17920.2
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
cytosol 1.000
ASURE: cytosol
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31975158 (2020): plastid
  • PMID:31520498 (2020): mitochondrion
  • PMID:31023727 (2019): mitochondrion
  • PMID:29967049 (2018): plastid
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:24727099 (2014): mitochondrion
  • PMID:21533090 (2011): extracellular region plant-type cell wall
  • PMID:21166475 (2011): cytosol
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Cobalamin-independent synthase family protein
Curator
Summary (TAIR10)
Encodes a cytosolic cobalamin-independent methionine synthase, involved in methionine regeneration via the activated methyl cycle (SAM cycle). The protein undergoes thiolation following treatment with the oxidant tert-butylhydroperoxide.
Computational
Description (TAIR10)
COBALAMIN-INDEPENDENT METHIONINE SYNTHASE (ATCIMS); FUNCTIONS IN: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity, methionine synthase activity; INVOLVED IN: response to zinc ion, response to salt stress, methionine biosynthetic process; LOCATED IN: in 6 components; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: seedling growth, seed development stages; CONTAINS InterPro DOMAIN/s: Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal (InterPro:IPR013215), Methionine synthase, vitamin-B12 independent (InterPro:IPR002629), 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase (InterPro:IPR006276); BEST Arabidopsis thaliana protein match is: methionine synthase 2 (TAIR:AT3G03780.3); Has 4442 Blast hits to 4434 proteins in 1682 species: Archae - 183; Bacteria - 3246; Metazoa - 14; Fungi - 206; Plants - 251; Viruses - 2; Other Eukaryotes - 540 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT5G17920-MONOMERBioCyc:ARA:GQT-1534-MONOMERBioGrid:16936BRENDA:2.1.1.14
EC:2.1.1.14eggNOG:COG0620eggNOG:KOG2263EMBL:AB011480
EMBL:AF370522EMBL:AJ608673EMBL:AY048201EMBL:AY056098
EMBL:AY057478EMBL:AY057499EMBL:AY069876EMBL:AY070771
EMBL:AY091692EMBL:BT000691EMBL:CP002688EMBL:U97200
EnsemblPlants:AT5G17920EnsemblPlants:AT5G17920.1EnsemblPlants:AT5G17920.2entrez:831660
EvolutionaryTrace:O50008GeneID:831660Genevisible:O50008GO:GO:0003871
GO:GO:0005507GO:GO:0005774GO:GO:0005777GO:GO:0005829
GO:GO:0005886GO:GO:0008270GO:GO:0008705GO:GO:0009506
GO:GO:0009507GO:GO:0009570GO:GO:0009651GO:GO:0010043
GO:GO:0016020GO:GO:0046686GO:GO:0048046GO:GO:0050667
Gramene:AT5G17920.1Gramene:AT5G17920.2gramene_pathway:2.1.1.14gramene_pathway:PWY-5041
gramene_pathway:PWY-702gramene_plant_reactome:1119400gramene_plant_reactome:6874919HAMAP:MF_00172
hmmpanther:PTHR30519hmmpanther:PTHR30519:SF0HOGENOM:HOG000246221InParanoid:O50008
IntAct:O50008InterPro:IPR002629InterPro:IPR006276InterPro:IPR013215
iPTMnet:O50008KEGG:00270+2.1.1.14KEGG:00450+2.1.1.14KEGG:ath:AT5G17920
KO:K00549OMA:RITNCEIPaxDb:O50008PDB:1U1H
PDB:1U1JPDB:1U1UPDB:1U22PDBsum:1U1H
PDBsum:1U1JPDBsum:1U1UPDBsum:1U22Pfam:O50008
Pfam:PF01717Pfam:PF08267PhylomeDB:O50008PIRSF:PIRSF000382
PRIDE:O50008PRO:PR:O50008ProteinModelPortal:O50008Proteomes:UP000006548
RefSeq:NP_001078599.1RefSeq:NP_197294.1SABIO-RK:O50008SMR:O50008
STRING:3702.AT5G17920.1SUPFAM:SSF51726SWISS-2DPAGE:O50008TAIR:AT5G17920
tair10-symbols:ATCIMSTIGRfam:TIGR01371TIGRFAMs:TIGR01371UniGene:At.22340
UniGene:At.24550UniGene:At.71028UniPathway:UPA00051UniProt:O50008
Coordinates (TAIR10) chr5:+:5935771..5939195
Molecular Weight (calculated) 84361.20 Da
IEP (calculated) 6.47
GRAVY (calculated) -0.14
Length 765 amino acids
Sequence (TAIR10)
(BLAST)
001: MASHIVGYPR MGPKRELKFA LESFWDGKST AEDLQKVSAD LRSSIWKQMS AAGTKFIPSN TFAHYDQVLD TTAMLGAVPP RYGYTGGEIG LDVYFSMARG
101: NASVPAMEMT KWFDTNYHYI VPELGPEVNF SYASHKAVNE YKEAKALGVD TVPVLVGPVS YLLLSKAAKG VDKSFELLSL LPKILPIYKE VITELKAAGA
201: TWIQLDEPVL VMDLEGQKLQ AFTGAYAELE STLSGLNVLV ETYFADIPAE AYKTLTSLKG VTAFGFDLVR GTKTLDLVKA GFPEGKYLFA GVVDGRNIWA
301: NDFAASLSTL QALEGIVGKD KLVVSTSCSL LHTAVDLINE TKLDDEIKSW LAFAAQKVVE VNALAKALAG QKDEALFSAN AAALASRRSS PRVTNEGVQK
401: AAAALKGSDH RRATNVSARL DAQQKKLNLP ILPTTTIGSF PQTVELRRVR REYKAKKVSE EDYVKAIKEE IKKVVDLQEE LDIDVLVHGE PERNDMVEYF
501: GEQLSGFAFT ANGWVQSYGS RCVKPPVIYG DVSRPKAMTV FWSAMAQSMT SRPMKGMLTG PVTILNWSFV RNDQPRHETC YQIALAIKDE VEDLEKGGIG
601: VIQIDEAALR EGLPLRKSEH AFYLDWAVHS FRITNCGVQD STQIHTHMCY SHFNDIIHSI IDMDADVITI ENSRSDEKLL SVFREGVKYG AGIGPGVYDI
701: HSPRIPSSEE IADRVNKMLA VLEQNILWVN PDCGLKTRKY TEVKPALKNM VDAAKLIRSQ LASAK
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)