AT4G32700.2
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : helicases;ATP-dependent helicases;nucleic acid binding;ATP binding;DNA-directed DNA polymerases;DNA binding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes a homolog of Drosophila MUS308 and mammalian DNA polymerase, which prevent spontaneous or DNA damage-induced production of DNA double strand breaks. Two conserved functional domains: an N-terminal superfamily II DNA/RNA helicase domain and a C-terminal prokaryotic-type DNA polymerase I domain. Required for regulated cell division and differentiation in meristems. Mutant plants show morphological defects, such as short roots, serrated leaves, and fasciation, as well as defective patterns of cell division and differentiation in the meristem. Mutant plants had 2.5 to 4.5-fold higher expression of ATGR1, ATBRCA1 and RAD51 genes. TEB is required for normal progression of DNA replication and for correct expression of genes during development. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
helicases;ATP-dependent helicases;nucleic acid binding;ATP binding;DNA-directed DNA polymerases;DNA binding; FUNCTIONS IN: in 6 functions; INVOLVED IN: regulation of gene expression, DNA replication, DNA recombination, photomorphogenesis; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA-directed DNA polymerase, family A, palm domain (InterPro:IPR001098), DNA/RNA helicase, C-terminal (InterPro:IPR001650), DNA polymerase A domain (InterPro:IPR002298), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: U5 small nuclear ribonucleoprotein helicase (TAIR:AT2G42270.1); Has 17628 Blast hits to 16579 proteins in 2941 species: Archae - 600; Bacteria - 7507; Metazoa - 1254; Fungi - 1190; Plants - 590; Viruses - 412; Other Eukaryotes - 6075 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr4:+:15767440..15779185 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 238537.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.94 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.35 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 2154 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MDSDSSKSRI DQFYVSKKRK HQSPNLKSGR NEKNVKVTGE RSPGDKGTLD SYLKASLDDK STTNSGLQAR QEAFTRKLDL EVSASSVGQN IHPCLPKPVS 0101: FATFKECLGQ NGSQDLHKEG VAAETHATDG LLCANQKDNS ELRDFATSFL SLYCSGVQSV VGSPPHQKEN ELKRRSSSSS LAQDIQISHK RRCESENIPS 0201: LDDLTNPLGS KPESLARNGN NRDKPVSDPT KKMPSNESVE IPMGLRKCSK APESSAHLTE FHTPGSAIKS CPVGTPKSGC GSSMFSPGEA FWNEAIQVAD 0301: GLTIPIENFG SVEAKVRDQH VTILSCSKKT DKCTEKLERS LDLDEIRVKD KDAIGFSKVV EKHGRDFNKE VYQLPVKNLE LLFQDKNING GIQERCASFD 0401: QNNITLGSSR ISESAFVGNK GCENLDIANN AQADKGLIGK MYPEPEGKKV LLCEENRGVR SVSMISNMRK PVGSSESEES HTPSSSHRNY DGLSLSTWLP 0501: SEVCSVYNKK GISKLYPWQV ECLQVDGVLQ KRNLVYCAST SAGKSFVAEV LMLRRVIRTG KMALLVLPYV SICAEKAEHL EVLLEPLGKH VRSYYGNQGG 0601: GTLPKDTSVA VCTIEKANSL INRLLEEGRL SELGIIVIDE LHMVGDQHRG YLLELMLTKL RYAAGEGSSE SSSGESSGTS SGKADPAHGL QIVGMSATMP 0701: NVGAVADWLQ AALYQTEFRP VPLEEYIKVG STIYNKKMEV VRTIPKAADM GGKDPDHIVE LCNEVVQEGN SVLIFCSSRK GCESTARHIS KLIKNVPVNV 0801: DGENSEFMDI RSAIDALRRS PSGVDPVLEE TLPSGVAYHH AGLTVEEREI VETCYRKGLV RVLTATSTLA AGVNLPARRV IFRQPMIGRD FIDGTRYKQM 0901: SGRAGRTGID TKGDSVLICK PGELKRIMAL LNETCPPLQS CLSEDKNGMT HAILEVVAGG IVQTAKDIHR YVRCTLLNST KPFQDVVKSA QDSLRWLCHR 1001: KFLEWNEETK LYTTTPLGRG SFGSSLCPEE SLIVLDDLLR AREGLVMASD LHLVYLVTPI NVGVEPNWEL YYERFMELSP LEQSVGNRVG VVEPFLMRMA 1101: HGATVRTLNR PQDVKKNLRG EYDSRHGSTS MKMLSDEQML RVCKRFFVAL ILSKLVQEAS VTEVCEAFKV ARGMVQALQE NAGRFSSMVS VFCERLGWHD 1201: LEGLVAKFQN RVSFGVRAEI VELTSIPYIK GSRARALYKA GLRTSQAIAE ASIPEIVKAL FESSAWAAEG TGQRRIHLGL AKKIKNGARK IVLEKAEEAR 1301: AAAFSAFKSL GLDVNELSKP LPLAPASSLN GQETTERDIS RGSVGPDGLQ QSIEGHMECE NFDMDNHREK PSEVLGDATL GVSSEINLTS RLPNFRPIGT 1401: AVGTNGPSAV SILSSDTFPI PVYDNREIKP KDNVEQHLTR NDHIPLSSNK DGTGEKGPVT AGNISGGFDS FLELWGSAGE FFFDLHYNKL QDLNSRISYE 1501: IHGIAICWNC SPVYYVNLNK DLPNLECVEK QKLIEDAVIG KSEVLASHNM LDVIKSRWNK ISKIMGNVNT RKFTWNLKVQ IQVLKSPAIS IQRCTRLNLP 1601: EGIRDELVDG SWLMMPPLHT SHTIDMSIVI WILWPDEERH SNPNIDKEVK KRLSPEAAEA ANRSGRWRNQ IRRVAHNGCC RRVAQTRALC SALWKILVSE 1701: ELLQALTTIE MPLVNVLADM ELWGIGIDIE GCLRARNILR DKLRSLEKKA FELAGMTFSL HNPADIANVL FGQLKLPIPE NQSKGKLHPS TDKHCLDLLR 1801: NEHPVVPIIK EHRTLAKLLN CTLGSICSLA KLRLSTQRYT LHGRWLQTST ATGRLSIEEP NLQSVEHEVE FKLDKNGRDV SSDADRYKIN ARDFFVPTQE 1901: NWLLLTADYS QIELRLMAHF SRDSSLISKL SQPEGDVFTM IAAKWTGKAE DSVSPHDRDQ TKRLIYGILY GMGANRLAEQ LECTSDEAKE KIRSFKSSFP 2001: AVTSWLNETI SFCQEKGYIQ TLKGRRRFLS KIKFGNAKEK SKAQRQAVNS MCQGSAADII KIAMINIYSA IAEDVDTAAS SSSSETRFHM LKGRCRILLQ 2101: VHDELVLEVD PSYVKLAAML LQTSMENAVS LLVPLHVKLK VGKTWGSLEP FQTD |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)