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AT4G08500.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
Description (TAIR10) protein_coding : MAPK/ERK kinase kinase 1
Curator
Summary (TAIR10)
Encodes a member of the A1 subgroup of the MEKK (MAPK/ERK kinase kinase) family. MEKK is another name for Mitogen-Activated Protein Kinase Kinase Kinase (MAPKKK or MAP3K). This subgroup has four members: At4g08500 (MEKK1, also known as ARAKIN, MAP3Kb1, MAPKKK8), At4g08480 (MEKK2, also known as MAP3Kb4, MAPKKK9), At4g08470 (MEKK3, also known as MAP3Kb3, MAPKKK10) and At4g12020 (MEKK4, also known as MAP3Kb5, MAPKKK11, WRKY19). Nomenclatures for mitogen-activated protein kinases are described in Trends in Plant Science 2002, 7(7):301. Mediates cold, salt, cadmium and wounding stress signalling. Phosphorylates MEK1.
Computational
Description (TAIR10)
MAPK/ERK kinase kinase 1 (MEKK1); FUNCTIONS IN: protein binding, kinase binding, DNA binding, MAP kinase kinase kinase activity, kinase activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: mitogen-activated protein kinase kinase kinase 9 (TAIR:AT4G08480.1); Has 132336 Blast hits to 130259 proteins in 4567 species: Archae - 142; Bacteria - 14700; Metazoa - 49430; Fungi - 12971; Plants - 32949; Viruses - 685; Other Eukaryotes - 21459 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT4G08500-MONOMERBioGrid:11709BRENDA:2.7.11.25EC:2.7.11.25
eggNOG:ENOG410XQGSeggNOG:KOG0198EMBL:AF076275EMBL:AL161511
EMBL:AY062459EMBL:BT000116EMBL:CP002687EMBL:D50468
EMBL:L43125EnsemblPlants:AT4G08500EnsemblPlants:AT4G08500.1entrez:826409
GeneID:826409Genevisible:Q39008GO:GO:0000165GO:GO:0000186
GO:GO:0003677GO:GO:0004674GO:GO:0004709GO:GO:0005524
GO:GO:0005634GO:GO:0005768GO:GO:0005886GO:GO:0006970
GO:GO:0009409GO:GO:0009611GO:GO:0009631GO:GO:0009651
GO:GO:0010449GO:GO:0019900GO:GO:0022622GO:GO:0045087
GO:GO:0046777GO:GO:1902065Gramene:AT4G08500.1hmmpanther:PTHR24361
hmmpanther:PTHR24361:SF318HOGENOM:HOG000239933InParanoid:Q39008IntAct:Q39008
InterPro:IPR000719InterPro:IPR008271InterPro:IPR011009InterPro:IPR017441
iPTMnet:Q39008KEGG:ath:AT4G08500KO:K13414OMA:NKPCLER
PaxDb:Q39008Pfam:PF00069Pfam:Q39008Pfscan:PS50011
PhylomeDB:Q39008PIR:T01833PRIDE:Q39008PRO:PR:Q39008
PROSITE:PS00107PROSITE:PS00108PROSITE:PS50011ProteinModelPortal:Q39008
Proteomes:UP000006548RefSeq:NP_192590.1scanprosite:PS00107scanprosite:PS00108
SMART:SM00220SMR:Q39008STRING:3702.AT4G08500.1SUPFAM:SSF56112
TAIR:AT4G08500tair10-symbols:ARAKINtair10-symbols:ATMEKK1tair10-symbols:MAPKKK8
tair10-symbols:MEKK1UniGene:At.21066UniProt:Q39008
Coordinates (TAIR10) chr4:-:5404272..5407062
Molecular Weight (calculated) 66028.10 Da
IEP (calculated) 5.36
GRAVY (calculated) -0.37
Length 608 amino acids
Sequence (TAIR10)
(BLAST)
001: MDRILARMKK STGRRGGDKN ITPVRRLERR DAARNINYDA ASCSSSSAED LSVSTSSLMT RSLEFPEPTS FRIGGGVGEM DRIYRSLGVS GPDDLAISFD
101: AWEACKKRSS SDVVNRFKSF DLDKVRDQDL SEEGPSGVVV GSDSMNHKVQ GQDLSEAGPS GGIVTELSEI GNLITPVDRL VADGVVENRR VMERTPTIVK
201: SKGYLVPNNV VAVGVGVGGG IKGLRPPVLK PPPAMKRPPI DHRGSSWDFL THFAPSETVK RPSSSSSSSE DGCDEEEGKE EEAEAEEMGA RFIQLGDTAD
301: ETCSFTTNEG DSSSTVSNTS PIYPDGGAII TSWQKGQLLG RGSFGSVYEG ISGDGDFFAV KEVSLLDQGS QAQECIQQLE GEIKLLSQLQ HQNIVRYRGT
401: AKDGSNLYIF LELVTQGSLL KLYQRYQLRD SVVSLYTRQI LDGLKYLHDK GFIHRDIKCA NILVDANGAV KLADFGLAKV SKFNDIKSCK GTPFWMAPEV
501: INRKDSDGYG SPADIWSLGC TVLEMCTGQI PYSDLEPVQA LFRIGRGTLP EVPDTLSLDA RLFILKCLKV NPEERPTAAE LLNHPFVRRP LPSVGSGGSG
601: SASPLLRR
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)