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AT3G48560.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
plastid 1.000
ASURE: plastid
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:31975158 (2020): plastid
  • PMID:31520498 (2020): mitochondrion
  • PMID:31186290 (2019): plastid plastid stroma
  • PMID:31023727 (2019): mitochondrion
  • PMID:30783145 (2019): extracellular region plant-type cell wall
  • PMID:30135097 (2018): plastid
  • PMID:29967049 (2018): plastid
  • PMID:27137770 (2016): plastid plastid stroma
  • PMID:25900983 (2015): Golgi
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:24361574 (2014): plastid plastid stroma
  • PMID:24124904 (2013): plastid
  • PMID:22550958 (2012): plastid
  • PMID:21531424 (2011): plastid
  • PMID:20061580 (2010): plastid plastid stroma
  • PMID:18431481 (2008): plastid plastid stroma
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : chlorsulfuron/imidazolinone resistant 1
Curator
Summary (TAIR10)
Catalyzes the formation of acetolactate from pyruvate, the first step in valine and isoleucine biosynthesis. Requires FAD, thiamine pyrophosphate and Mg. Inhibited by the sulphonylurea herbicide, chlorsulphuron, and the imidazolinone herbicide, imazapyr. The obtained crystal structure of acetohydroxyacid synthase AHAS, EC 2.2.1.6)in complex with herbicides of the sulphonylurea and imidazolinone family reveals the molecular basis for substrate/inhibitor binding.
Computational
Description (TAIR10)
chlorsulfuron/imidazolinone resistant 1 (CSR1); FUNCTIONS IN: acetolactate synthase activity, pyruvate decarboxylase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: TPP-binding enzyme, conserved site (InterPro:IPR000399), Thiamine pyrophosphate enzyme, central domain (InterPro:IPR012000), Acetolactate synthase, large subunit, biosynthetic (InterPro:IPR012846), Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain (InterPro:IPR012001), Thiamine pyrophosphate enzyme, C-terminal TPP-binding (InterPro:IPR011766); BEST Arabidopsis thaliana protein match is: Thiamine pyrophosphate dependent pyruvate decarboxylase family protein (TAIR:AT5G17380.1); Has 30963 Blast hits to 30605 proteins in 2694 species: Archae - 488; Bacteria - 17421; Metazoa - 266; Fungi - 871; Plants - 599; Viruses - 25; Other Eukaryotes - 11293 (source: NCBI BLink).
Protein Annotations
BindingDB:P17597BioCyc:ARA:AT3G48560-MONOMERBioGrid:9334BRENDA:2.2.1.6
ChEMBL:CHEMBL4263DIP:DIP-61092NEC:2.2.1.6eggNOG:COG0028
eggNOG:KOG4166EMBL:AL133315EMBL:AY042819EMBL:AY124092
EMBL:BT020540EMBL:CP002686EMBL:DQ991161EMBL:X51514
EnsemblPlants:AT3G48560EnsemblPlants:AT3G48560.1entrez:824015EvolutionaryTrace:P17597
Gene3D:3.40.50.1220Gene3D:3.40.50.970GeneID:824015Genevisible:P17597
GO:GO:0000287GO:GO:0003984GO:GO:0009097GO:GO:0009099
GO:GO:0009507GO:GO:0009570GO:GO:0009635GO:GO:0030976
GO:GO:0050660Gramene:AT3G48560.1gramene_pathway:2.2.1.6gramene_pathway:ILEUSYN-PWY
gramene_pathway:VALSYN-PWYgramene_plant_reactome:1119460gramene_plant_reactome:1119600gramene_plant_reactome:6873698
gramene_plant_reactome:6874293hmmpanther:PTHR18968hmmpanther:PTHR18968:SF112HOGENOM:HOG000258448
InParanoid:P17597InterPro:IPR000399InterPro:IPR011766InterPro:IPR012000
InterPro:IPR012001InterPro:IPR012846InterPro:IPR029035InterPro:IPR029061
KEGG:00290+2.2.1.6KEGG:00650+2.2.1.6KEGG:00660+2.2.1.6KEGG:00770+2.2.1.6
KEGG:ath:AT3G48560KO:K01652ncoils:CoilOMA:HSWVVRD
PaxDb:P17597PDB:1YBHPDB:1YHYPDB:1YHZ
PDB:1YI0PDB:1YI1PDB:1Z8NPDB:3E9Y
PDB:3EA4PDBsum:1YBHPDBsum:1YHYPDBsum:1YHZ
PDBsum:1YI0PDBsum:1YI1PDBsum:1Z8NPDBsum:3E9Y
PDBsum:3EA4Pfam:P17597Pfam:PF00205Pfam:PF02775
Pfam:PF02776PhylomeDB:P17597PIR:S09502PRIDE:P17597
PRO:PR:P17597PROSITE:PS00187ProteinModelPortal:P17597Proteomes:UP000006548
RefSeq:NP_190425.1SABIO-RK:P17597scanprosite:PS00187SMR:P17597
STRING:3702.AT3G48560.1SUPFAM:SSF52467SUPFAM:SSF52518TAIR:AT3G48560
tair10-symbols:AHAStair10-symbols:ALStair10-symbols:CSR1tair10-symbols:IMR1
tair10-symbols:TZP5TIGRfam:TIGR00118TIGRFAMs:TIGR00118UniGene:At.22295
UniGene:At.72000UniPathway:UPA00047UniPathway:UPA00049UniProt:P17597
Coordinates (TAIR10) chr3:-:18001530..18003542
Molecular Weight (calculated) 72589.20 Da
IEP (calculated) 6.63
GRAVY (calculated) -0.13
Length 670 amino acids
Sequence (TAIR10)
(BLAST)
001: MAAATTTTTT SSSISFSTKP SPSSSKSPLP ISRFSLPFSL NPNKSSSSSR RRGIKSSSPS SISAVLNTTT NVTTTPSPTK PTKPETFISR FAPDQPRKGA
101: DILVEALERQ GVETVFAYPG GASMEIHQAL TRSSSIRNVL PRHEQGGVFA AEGYARSSGK PGICIATSGP GATNLVSGLA DALLDSVPLV AITGQVPRRM
201: IGTDAFQETP IVEVTRSITK HNYLVMDVED IPRIIEEAFF LATSGRPGPV LVDVPKDIQQ QLAIPNWEQA MRLPGYMSRM PKPPEDSHLE QIVRLISESK
301: KPVLYVGGGC LNSSDELGRF VELTGIPVAS TLMGLGSYPC DDELSLHMLG MHGTVYANYA VEHSDLLLAF GVRFDDRVTG KLEAFASRAK IVHIDIDSAE
401: IGKNKTPHVS VCGDVKLALQ GMNKVLENRA EELKLDFGVW RNELNVQKQK FPLSFKTFGE AIPPQYAIKV LDELTDGKAI ISTGVGQHQM WAAQFYNYKK
501: PRQWLSSGGL GAMGFGLPAA IGASVANPDA IVVDIDGDGS FIMNVQELAT IRVENLPVKV LLLNNQHLGM VMQWEDRFYK ANRAHTFLGD PAQEDEIFPN
601: MLLFAAACGI PAARVTKKAD LREAIQTMLD TPGPYLLDVI CPHQEHVLPM IPSGGTFNDV ITEGDGRIKY
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)