AT3G22590.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 0.996 What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : PLANT HOMOLOGOUS TO PARAFIBROMIN | ||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC). | ||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP); CONTAINS InterPro DOMAIN/s: RNA polymerase II accessory factor, Cdc73 (InterPro:IPR007852); Has 502 Blast hits to 395 proteins in 198 species: Archae - 0; Bacteria - 0; Metazoa - 257; Fungi - 127; Plants - 42; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr3:+:8003999..8005452 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 47546.30 Da | ||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.62 | ||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.63 | ||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 415 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
001: MDPLSVLKEF TIRGDIDKIE RVGANYRFGS EYSFPCATET AYRSKSGSLY TLEALVHYVK NQQLKHGEYM QSTVKNSVPA VTLPDRKPLL DYLTGRVASS 101: DSIDFLLLQQ QNAQSQKQNE EYRPDQDNSA FVSRENAIAD MEVEDFGKSG EDVDYIMLIR SNERPLKSRD AILQCKNRDF YSVLVNSTKR EEERQRIESH 201: QRKDGLVAKS RLMGAEERGI VGFSSGGGDD NGYDANPKSK LHFKAGKIGE GVPIILVPSA FQTLITIYNV KEFLEDGVYI PNDVKAKEMK GLKPDCITVQ 301: KKFSRDRERV VTAYEVRDKP SALKPDDWDR VVAVFVLGKD WQFKDWPFKD HVEIFNKIIG FFLRFEDDSI ESAKTVKQWN VKIISISKNK RHQDRAAALE 401: VWEKLEEFVR SRSHS |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)