AT2G36490.1
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Subcellular Consensus
(Prediction and Experimental) min:  :max.
SUBAcon:nucleus 1.000 ASURE: nucleus What is SUBAcon? |
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| Experimental Localisations and PPI |
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SUBAcon links
AGI-AGI relationships |
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| Description (TAIR10) | protein_coding : demeter-like 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Curator Summary (TAIR10) |
A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Computational Description (TAIR10) |
demeter-like 1 (DML1); FUNCTIONS IN: protein binding, DNA N-glycosylase activity, DNA-(apurinic or apyrimidinic site) lyase activity; INVOLVED IN: DNA repair, chromatin silencing, negative regulation of chromatin silencing, DNA methylation, DNA demethylation; LOCATED IN: nucleus; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA glycosylase (InterPro:IPR011257), Endonuclease III-like, iron-sulphur cluster loop motif (InterPro:IPR003651), HhH-GPD domain (InterPro:IPR003265); BEST Arabidopsis thaliana protein match is: HhH-GPD base excision DNA repair family protein (TAIR:AT5G04560.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink). | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Annotations |
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| Coordinates (TAIR10) | chr2:-:15308259..15314272 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Molecular Weight (calculated) | 156556.00 Da | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IEP (calculated) | 7.38 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GRAVY (calculated) | -0.66 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Length | 1393 amino acids | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence (TAIR10) (BLAST) |
0001: MEKQRREESS FQQPPWIPQT PMKPFSPICP YTVEDQYHSS QLEERRFVGN KDMSGLDHLS FGDLLALANT ASLIFSGQTP IPTRNTEVMQ KGTEEVESLS 0101: SVSNNVAEQI LKTPEKPKRK KHRPKVRREA KPKREPKPRA PRKSVVTDGQ ESKTPKRKYV RKKVEVSKDQ DATPVESSAA VETSTRPKRL CRRVLDFEAE 0201: NGENQTNGDI REAGEMESAL QEKQLDSGNQ ELKDCLLSAP STPKRKRSQG KRKGVQPKKN GSNLEEVDIS MAQAAKRRQG PTCCDMNLSG IQYDEQCDYQ 0301: KMHWLYSPNL QQGGMRYDAI CSKVFSGQQH NYVSAFHATC YSSTSQLSAN RVLTVEERRE GIFQGRQESE LNVLSDKIDT PIKKKTTGHA RFRNLSSMNK 0401: LVEVPEHLTS GYCSKPQQNN KILVDTRVTV SKKKPTKSEK SQTKQKNLLP NLCRFPPSFT GLSPDELWKR RNSIETISEL LRLLDINREH SETALVPYTM 0501: NSQIVLFGGG AGAIVPVTPV KKPRPRPKVD LDDETDRVWK LLLENINSEG VDGSDEQKAK WWEEERNVFR GRADSFIARM HLVQGDRRFT PWKGSVVDSV 0601: VGVFLTQNVS DHLSSSAFMS LASQFPVPFV PSSNFDAGTS SMPSIQITYL DSEETMSSPP DHNHSSVTLK NTQPDEEKDY VPSNETSRSS SEIAISAHES 0701: VDKTTDSKEY VDSDRKGSSV EVDKTDEKCR VLNLFPSEDS ALTCQHSMVS DAPQNTERAG SSSEIDLEGE YRTSFMKLLQ GVQVSLEDSN QVSPNMSPGD 0801: CSSEIKGFQS MKEPTKSSVD SSEPGCCSQQ DGDVLSCQKP TLKEKGKKVL KEEKKAFDWD CLRREAQARA GIREKTRSTM DTVDWKAIRA ADVKEVAETI 0901: KSRGMNHKLA ERIQGFLDRL VNDHGSIDLE WLRDVPPDKA KEYLLSFNGL GLKSVECVRL LTLHHLAFPV DTNVGRIAVR LGWVPLQPLP ESLQLHLLEM 1001: YPMLESIQKY LWPRLCKLDQ KTLYELHYQM ITFGKVFCTK SKPNCNACPM KGECRHFASA FASARLALPS TEKGMGTPDK NPLPLHLPEP FQREQGSEVV 1101: QHSEPAKKVT CCEPIIEEPA SPEPETAEVS IADIEEAFFE DPEEIPTIRL NMDAFTSNLK KIMEHNKELQ DGNMSSALVA LTAETASLPM PKLKNISQLR 1201: TEHRVYELPD EHPLLAQLEK REPDDPCSYL LAIWTPGETA DSIQPSVSTC IFQANGMLCD EETCFSCNSI KETRSQIVRG TILIPCRTAM RGSFPLNGTY 1301: FQVNEVFADH ASSLNPINVP RELIWELPRR TVYFGTSVPT IFKGLSTEKI QACFWKGYVC VRGFDRKTRG PKPLIARLHF PASKLKGQQA NLA |
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| See Also |
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Citation
If you find this resource useful please cite one of the following publications:
Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)
Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)