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AT1G48050.1
Subcellular Consensus
(Prediction and Experimental)
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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:28865150 (2017): extracellular region plant-type cell wall
  • PMID:25900983 (2015): Golgi trans-Golgi network early endosome
  • PMID:25900983 (2015): Golgi trans-Golgi network multivesicular body
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : Ku80 family protein
Curator
Summary (TAIR10)
Ku80 and ku70 form the heterodimer complex Ku, required for proper maintenance of the telomeric C strand. Ku regulates the extension of the telomeric G strand. Interacts with WEX, and this interaction stimulates the WEX exonuclease activity. Binds double stranded DNA breaks as a heterodimer with Ku70, involved in non-homologous end joining repair. Mutants are defective in T-DNA integration. Over expression confers increased resistance to DNA damage agents and increased susceptibility to T-DNA transformation.
Computational
Description (TAIR10)
KU80; FUNCTIONS IN: double-stranded DNA binding, protein binding; INVOLVED IN: in 6 processes; LOCATED IN: nucleus; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ku70/Ku80, N-terminal alpha/beta (InterPro:IPR005161), DNA helicase, ATP-dependent, Ku type (InterPro:IPR006164), Spen Paralogue and Orthologue SPOC, C-terminal-like (InterPro:IPR016194), Ku70/Ku80 C-terminal arm (InterPro:IPR005160), Ku, C-terminal (InterPro:IPR014893); Has 786 Blast hits to 750 proteins in 217 species: Archae - 0; Bacteria - 40; Metazoa - 246; Fungi - 345; Plants - 62; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:GQT-2275-MONOMERBioGrid:26448EC:3.6.4.12eggNOG:ENOG410YKH9
eggNOG:KOG2326EMBL:AC023673EMBL:AC051631EMBL:AF283758
EMBL:CP002684EnsemblPlants:AT1G48050EnsemblPlants:AT1G48050.1entrez:841223
Gene3D:1.10.1600.10Gene3D:1.25.40.240Gene3D:2.40.290.10Gene3D:3.40.50.410
GeneID:841223Genevisible:Q9FQ09GO:GO:0000723GO:GO:0000784
GO:GO:0003684GO:GO:0003690GO:GO:0004003GO:GO:0005524
GO:GO:0005737GO:GO:0006281GO:GO:0006302GO:GO:0006303
GO:GO:0006310GO:GO:0009408GO:GO:0015074GO:GO:0032508
GO:GO:0042162GO:GO:0043564GO:GO:0071480GO:GO:0071481
Gramene:AT1G48050.1hmmpanther:PTHR12604hmmpanther:PTHR12604:SF4HOGENOM:HOG000006137
InParanoid:Q9FQ09IntAct:Q9FQ09InterPro:IPR002035InterPro:IPR005160
InterPro:IPR005161InterPro:IPR006164InterPro:IPR014893InterPro:IPR016194
InterPro:IPR024193iPTMnet:Q9FQ09KEGG:ath:AT1G48050KO:K10885
MINT:MINT-1212609OMA:YTFRESLPANTHER:PTHR12604:SF4PaxDb:Q9FQ09
Pfam:PF02735Pfam:PF03730Pfam:PF03731Pfam:PF08785
Pfam:Q9FQ09PhylomeDB:Q9FQ09PIR:G96520PIRSF:PIRSF016570
PRIDE:Q9FQ09PRO:PR:Q9FQ09ProteinModelPortal:Q9FQ09Proteomes:UP000006548
RefSeq:NP_564520.1SMART:SM00559SMR:Q9FQ09STRING:3702.AT1G48050.1
SUPFAM:0049250SUPFAM:SSF100939SUPFAM:SSF101420SUPFAM:SSF53300
TAIR:AT1G48050tair10-symbols:ATKU80tair10-symbols:KU80UniGene:At.42965
UniProt:Q9FQ09
Coordinates (TAIR10) chr1:+:17723498..17726859
Molecular Weight (calculated) 76692.40 Da
IEP (calculated) 5.37
GRAVY (calculated) -0.40
Length 680 amino acids
Sequence (TAIR10)
(BLAST)
001: MARNREGLVL VLDVGPAMRS VLPDVEKACS MLLQKKLIYN KYDEVGIVVF GTEETGNELA REIGGYENVT VLRNIRVVDE LAAEHVKQLP RGTVAGDFLD
101: ALIVGMDMLI KMYGNAHKGK KRMCLITNAA CPTKDPFEGT KDDQVSTIAM KMAAEGIKME SIVMRSNLSG DAHERVIEEN DHLLTLFSSN AIAKTVNVDS
201: PLSLLGSLKT RRVAPVTLFR GDLEINPTMK IKVWVYKKVA EERLPTLKMY SDKAPPTDKF AKHEVKVDYD YKVTAESTEV IAPEERIKGF RYGPQVIPIS
301: PDQIETLKFK TDKGMKLLGF TEASNILRHY YMKDVNIVVP DPSKEKSVLA VSAIAREMKE TNKVAIVRCV WRNGQGNVVV GVLTPNVSER DDTPDSFYFN
401: VLPFAEDVRE FPFPSFNKLP SSWKPDEQQQ AVADNLVKML DLAPSAEEEV LKPDLTPNPV LQRFYEYLEL KSKSTDATLP PMDGTFKRLM EQDPELSSNN
501: KSIMDTFRGS FEVKENPKLK KASKRLLRDK PSGSDDEDNR MITYDAKENK IDIVGDANPI QDFEAMISRR DKTDWTEKAI TQMKNLIMKL VENCTDEGDK
601: ALECVLALRK GCVLEQEPKQ FNEFLNHLFK LCQERNLSHL LEHFMSKKIT LIPKSEAADS DIVDENAGDF IVKQESMLES
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)