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AT1G08260.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
nucleus 1.000
ASURE: nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
  • PMID:30783145 (2019): extracellular region plant-type cell wall
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DNA polymerase epsilon catalytic subunit
Curator
Summary (TAIR10)
Similar to POL2A, DNA polymerase epsilon catalytic subunit. Essential for Arabidopsis growth. Null homozygotes are embryo lethal, partial loss of function alleles show embryo patterning defects such as root pole displacement. Delayed progression through cell cycle results in embryos with smaller numbers of larger cells.
Computational
Description (TAIR10)
TILTED 1 (TIL1); FUNCTIONS IN: DNA-directed DNA polymerase activity, DNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: positive regulation of S phase of mitotic cell cycle, negative regulation of long-day photoperiodism, flowering, embryo development ending in seed dormancy; LOCATED IN: apoplast, epsilon DNA polymerase complex; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: DNA polymerase, family B (InterPro:IPR022762), DNA-directed DNA polymerase, family B, exonuclease domain (InterPro:IPR006133), Domain of unknown function DUF1744 (InterPro:IPR013697), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), DNA-directed DNA polymerase, family B, conserved region (InterPro:IPR006134); BEST Arabidopsis thaliana protein match is: DNA polymerase epsilon catalytic subunit (TAIR:AT2G27120.1); Has 2011 Blast hits to 1700 proteins in 652 species: Archae - 331; Bacteria - 603; Metazoa - 305; Fungi - 291; Plants - 83; Viruses - 58; Other Eukaryotes - 340 (source: NCBI BLink).
Protein Annotations
EC:2.7.7.7eggNOG:COG0417eggNOG:KOG1798EMBL:AC011438
EMBL:CP002684EnsemblPlants:AT1G08260EnsemblPlants:AT1G08260.1entrez:837346
Gene3D:3.30.420.10GeneID:837346Genevisible:F4HW04GO:GO:0000166
GO:GO:0003677GO:GO:0003887GO:GO:0006260GO:GO:0008270
GO:GO:0008408GO:GO:0008622GO:GO:0051539Gramene:AT1G08260.1
hmmpanther:PTHR10670InParanoid:F4HW04InterPro:IPR006133InterPro:IPR006134
InterPro:IPR006172InterPro:IPR012337InterPro:IPR013697InterPro:IPR029703
iPTMnet:F4HW04KEGG:00230+2.7.7.7KEGG:00240+2.7.7.7KEGG:ath:AT1G08260
KO:K02324ncoils:CoilOMA:MDMEDIGPANTHER:PTHR10670
PaxDb:F4HW04Pfam:F4HW04Pfam:PF00136Pfam:PF03104
Pfam:PF08490PRIDE:F4HW04PRO:PR:F4HW04ProteinModelPortal:F4HW04
Proteomes:UP000006548Reactome:R-ATH-174430Reactome:R-ATH-68952Reactome:R-ATH-68962
RefSeq:NP_172303.5SMART:SM00486SMART:SM01159STRING:3702.AT1G08260.1
SUPFAM:SSF53098SUPFAM:SSF56672TAIR:AT1G08260tair10-symbols:ABO4
tair10-symbols:EMB142tair10-symbols:EMB2284tair10-symbols:EMB529tair10-symbols:ESD7
tair10-symbols:POL2Atair10-symbols:TIL1UniGene:At.42268UniGene:At.51528
UniProt:F4HW04
Coordinates (TAIR10) chr1:+:2590944..2606892
Molecular Weight (calculated) 248910.00 Da
IEP (calculated) 6.55
GRAVY (calculated) -0.38
Length 2161 amino acids
Sequence (TAIR10)
(BLAST)
0001: MSGDNRRRDR KDTRWSKKPK VVNTAEDELE SKLGFGLFSE GETRLGWLLT FSSSSWEDRD TGKVYSCVDL YFVTQDGFSF KTKYKFRPYF YAATKDKMEL
0101: ELEAYLRRRY ERQVADIEIV EKEDLDLKNH LSGLQKKYLK ISFDTVQQLM EVKRDLLHIV ERNQAKFDAL EAYESILAGK REQRPQDCLD SIVDLREYDV
0201: PYHVRFAIDN DVRSGQWYNV SISSTDVILE KRTDLLQRAE VRVCAFDIET TKLPLKFPDA EYDQIMMISY MVDGQGFLII NRECVGEDVE DLEYTPKPEF
0301: EGYFKVTNVK NEVELLQRWF YHMQELKPGI YVTYNGDFFD WPFIERRASH HGIKMNEELG FRCDQNQGEC RAKFACHLDC FAWVKRDSYL PQGSHGLKAV
0401: TKAKLGYDPL EVNPEDMVRF AMEKPQTMAS YSVSDAVATY YLYMTYVNPF IFSLATIIPM VPDEVLRKGS GTLCEMLLMV EAYKANVVCP NKNQADPEKF
0501: YQNQLLESET YIGGHVECLE SGVFRSDIPT SFKLDSSAYQ QLIDNLGRDL EYAITVEGKM RMDSISNYDE VKDEIKEKLE KLRDDPIREE GPLIYHLDVA
0601: AMYPNIILTN RLQPPSIVTD EICTACDFNR PGKTCLRKLE WVWRGVTFMG KKSDYYHLKK QIESEFVDAG ANIMSSKSFL DLPKVDQQSK LKERLKKYCQ
0701: KAYKRVLDKP ITEVREAGIC MRENPFYVDT VRSFRDRRYE YKTLNKVWKG KLSEAKASGN SIKIQEAQDM VVVYDSLQLA HKCILNSFYG YVMRKGARWY
0801: SMEMAGVVTY TGAKIIQNAR LLIERIGKPL ELDTDGIWCC LPGSFPENFT FKTIDMKKLT ISYPCVMLNV DVAKNNTNDQ YQTLVDPVRK TYKSHSECSI
0901: EFEVDGPYKA MIIPASKEEG ILIKKRYAVF NHDGTLAELK GFEIKRRGEL KLIKVFQAEL FDKFLHGSTL EECYSAVAAV ADRWLDLLDN QGKDIADSEL
1001: LDYISESSTM SKSLADYGEQ KSCAVTTAKR LAEFLGVTMV KDKGLRCQYI VACEPKGTPV SERAVPVAIF TTNPEVMKFH LRKWCKTSSD VGIRLIIDWS
1101: YYKQRLSSAI QKVITIPAAM QKVANPVPRV LHPDWLHKKV REKDDKFRQR KLVDMFSSAN KDVVLDTDLP VTKDNVEDIE DFCKENRPSV KGPKPIARSY
1201: EVNKKQSECE QQESWDTEFH DISFQNIDKS VNYQGWLELK KRKWKVTLEK KKKRRLGDLR SSNQVDTHEI NQKVGQGRGG VGSYFRRPEE ALTSSHWQII
1301: QLVPSPQSGQ FFAWVVVEGL MLKIPLSIPR VFYINSKVPI DEYFQGKCVN KILPHGRPCY SLTEVKIQED QFKKESKKRA ALLADPGVEG IYETKVPLEF
1401: SAICQIGCVC KIDNKAKHRN TQDGWEVGEL HMKTTTECHY LKRSIPLVYL YNSTSTGRAI YVLYCHVSKL MSAVVVDPFN GNELLPSALE RQFRDSCLEL
1501: SLDSLSWDGI RFQVHYVDHP EAAKKIIQRA ISEYREENCG PTVAVIECPD FTFMKEGIKA LDDFPCVRIP FNDDDNSYQP VSWQRPAAKI AMFRCAAAFQ
1601: WLDRRITQSR YAHVPLGNFG LDWLTFTIDI FLSRALRDQQ QVLWVSDNGV PDLGGINNEE AFFADEVQQT SLVFPGAYRK VSVELKIHNL AVNALLKSNL
1701: VNEMEGGGFM GFEQDVNPRG INSNDNTSFD ETTGCAQAFR VLKQLIHSCL TDVRKSKNIY ADSILQRLSW WLCSPSSKLH DPALHLMLHK VMQKVFALLL
1801: TDLRRLGAII IYADFSKVII DTVKFDLSAA KAYCESLLST VRNSDIFEWI LLEPVHYWHS LLFMDQYNYA GIRADDEISL DEVTIEPKWS VARHLPEYIE
1901: RDFIIIIAKF IFDPWKFAIE NKKGSSESLE AQMIEYLREQ IGSTFINMLV KKVDDIMSHM KEINVSDASR VSGQAPKGDY SLEFIQVISA VLALDQNVQQ
2001: DVLVMRKSLL KYIKVKECAA EAEFLDPGPS FILPNVACSN CDAYRDLDIC RDPALLTEKE WSCADTQCGK IYDREQMESS LLEMVRQRER MYHMQDVVCI
2101: RCNQVKAAHL TEQCECSGSF RCKESGSEFS KRMEIFMDIA KRQKFRLLEE YISWIIYGPS Y
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)