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AT1G08130.1
Subcellular Consensus
(Prediction and Experimental)
min: heatmap :max

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SUBAcon:
mitochondrion 0.500
nucleus 0.500
ASURE: mitochondrion,nucleus
What is SUBAcon?
Experimental Localisations and PPI
FP MS/MS PPI
SUBAcon links
AGI-AGI relationships
Coexpression PPI
no PPI data
Description (TAIR10) protein_coding : DNA ligase 1
Curator
Summary (TAIR10)
Encodes the Arabidopsis DNA ligase 1 that provides the major DNA ligase activity in cells and plays a key role in both DNA replication and excision repair pathways. Indispensable for cell viability. AtLIG1 expresses one major and two minor mRNA transcripts differing only in the length of the 5' untranslated leader sequences preceding a common ORF. Translation from the first in-frame start codon produces an AtLIG1 isoform that is targeted exclusively to the mitochondria. Translation initiation from the second in-frame start codon produces an AtLIG1 isoform targeted only to the nucleus.
Computational
Description (TAIR10)
DNA ligase 1 (LIG1); FUNCTIONS IN: DNA binding, DNA ligase (ATP) activity, ATP binding; INVOLVED IN: DNA repair, DNA replication, DNA recombination; LOCATED IN: mitochondrion, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold (InterPro:IPR012340), DNA ligase, N-terminal (InterPro:IPR012308), ATP dependent DNA ligase, central (InterPro:IPR012310), ATP dependent DNA ligase, C-terminal (InterPro:IPR012309), ATP-dependent DNA ligase (InterPro:IPR000977), ATP-dependent DNA ligase, conserved site (InterPro:IPR016059); BEST Arabidopsis thaliana protein match is: ATP-dependent DNA ligase (TAIR:AT1G49250.1); Has 3556 Blast hits to 3521 proteins in 879 species: Archae - 298; Bacteria - 1538; Metazoa - 375; Fungi - 434; Plants - 112; Viruses - 159; Other Eukaryotes - 640 (source: NCBI BLink).
Protein Annotations
BioCyc:ARA:AT1G08130-MONOMEREC:6.5.1.1eggNOG:COG1793eggNOG:KOG0967
EMBL:AC011438EMBL:AC026875EMBL:AK117238EMBL:AK222166
EMBL:BT005964EMBL:CP002684EMBL:X97924EnsemblPlants:AT1G08130
EnsemblPlants:AT1G08130.1entrez:837333Gene3D:1.10.3260.10Gene3D:2.40.50.140
GeneID:837333Genevisible:Q42572GO:GO:0000012GO:GO:0003677
GO:GO:0003910GO:GO:0005524GO:GO:0005634GO:GO:0005730
GO:GO:0005739GO:GO:0006260GO:GO:0006273GO:GO:0006302
GO:GO:0006310GO:GO:0007049GO:GO:0046872GO:GO:0051103
GO:GO:0051301GO:GO:0071897GO:GO:0080111hmmpanther:PTHR10459
hmmpanther:PTHR10459:SF10HOGENOM:HOG000036006InParanoid:Q42572InterPro:IPR000977
InterPro:IPR012308InterPro:IPR012309InterPro:IPR012310InterPro:IPR012340
InterPro:IPR016059KEGG:ath:AT1G08130KO:K10747OMA:SQCPNYD
PaxDb:Q42572Pfam:PF01068Pfam:PF04675Pfam:PF04679
Pfam:Q42572Pfscan:PS50160PhylomeDB:Q42572PIR:S71278
PRIDE:Q42572PRO:PR:Q42572PROSITE:PS00333PROSITE:PS00697
PROSITE:PS50160ProteinModelPortal:Q42572Proteomes:UP000006548Reactome:R-ATH-110362
Reactome:R-ATH-174414Reactome:R-ATH-5358565Reactome:R-ATH-5358606Reactome:R-ATH-5651801
Reactome:R-ATH-6782210Reactome:R-ATH-69183RefSeq:NP_172293.2scanprosite:PS00333
scanprosite:PS00697SMR:Q42572STRING:3702.AT1G08130.1SUPFAM:0050884
SUPFAM:SSF117018SUPFAM:SSF50249SUPFAM:SSF56091TAIR:AT1G08130
tair10-symbols:ATLIG1tair10-symbols:LIG1TIGRfam:TIGR00574TIGRFAMs:TIGR00574
UniGene:At.36UniProt:Q42572
Coordinates (TAIR10) chr1:-:2542913..2547815
Molecular Weight (calculated) 87745.10 Da
IEP (calculated) 8.10
GRAVY (calculated) -0.34
Length 790 amino acids
Sequence (TAIR10)
(BLAST)
001: MLAIRSSNYL RCIPSLCTKT QISQFSSVLI SFSRQISHLR LSSCHRAMSS SRPSAFDALM SNARAAAKKK TPQTTNLSRS PNKRKIGETQ DANLGKTIVS
101: EGTLPKTEDL LEPVSDSANP RSDTSSIAED SKTGAKKAKT LSKTDEMKSK IGLLKKKPND FDPEKMSCWE KGERVPFLFV ALAFDLISNE SGRIVITDIL
201: CNMLRTVIAT TPEDLVATVY LSANEIAPAH EGVELGIGES TIIKAISEAF GRTEDHVKKQ NTELGDLGLV AKGSRSTQTM MFKPEPLTVV KVFDTFRQIA
301: KESGKDSNEK KKNRMKALLV ATTDCEPLYL TRLLQAKLRL GFSGQTVLAA LGQAAVYNEE HSKPPPNTKS PLEEAAKIVK QVFTVLPVYD IIVPALLSGG
401: VWNLPKTCNF TLGVPIGPML AKPTKGVAEI LNKFQDIVFT CEYKYDGERA QIHFMEDGTF EIYSRNAERN TGKYPDVALA LSRLKKPSVK SFILDCEVVA
501: FDREKKKILP FQILSTRARK NVNVNDIKVG VCIFAFDMLY LNGQQLIQEN LKIRREKLYE SFEEDPGYFQ FATAVTSNDI DEIQKFLDAS VDVGCEGLII
601: KTLDSDATYE PAKRSNNWLK LKKDYMDSIG DSVDLVPIAA FHGRGKRTGV YGAFLLACYD VDKEEFQSIC KIGTGFSDAM LDERSSSLRS QVIATPKQYY
701: RVGDSLNPDV WFEPTEVWEV KAADLTISPV HRAATGIVDP DKGISLRFPR LLRVREDKKP EEATSSEQIA DLYQAQKHNH PSNEVKGDDD
See Also
Citation
If you find this resource useful please cite one of the following publications:

Hooper CM, Castleden I, Tanz SK, Aryamanesh, and Millar, AH (2017) SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations Nucleic Acids Res. Jan 4;45(D1):D1064-D1074. doi: 10.1093/nar/gkw1041 (PubMed)

Hooper CM, Tanz SK, Castleden IR, Vacher MA, Small ID, Millar AH (2014) "SUBAcon: a consensus algorithm for unifying the subcellular localization data of the Arabidopsis proteome. Bioinformatics." 1;30(23):3356-64. (Bioinformatics) (PubMed)